Pfizer bivalent booster side effects : Pfizer bivalent booster, or Pfizer-BioNTech COVID-19 vaccine booster, is not yet publicly available. Therefore, there is no specific data on its side effects. However, based on previous COVID-19 vaccines, common side effects may include pain at the injection site, fatigue, headache, muscle pain, chills, fever, and nausea. These side effects are usually mild and temporary.